Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.51 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7321880 | 0.87 | ORAI1 (1.00) | ORAI1EPHX2SMN1; SMN2MAPTLMNA | |
| SCHEMBL5208645 | 0.87 | ORAI1 (1.00) | ORAI1EPHX2SMN1; SMN2MAPTLMNA | |
| SCHEMBL13429392 | 0.84 | MAPT (0.69) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL12292897 | 0.84 | ORAI1 (0.56) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL13429395 | 0.84 | ORAI1 (0.56) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL16202075 | 0.83 | POLB (0.55) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7319875 | 0.82 | ORAI1 (0.78) | ORAI1KMT2ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL2420987 | 0.81 | ORAI1 (0.52) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL13429393 | 0.81 | MAPT (0.56) | ORAI1MEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL7325708 | 0.81 | ORAI1 (0.79) | ORAI1EPHX2MAPTTRPC3TRPC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048559-A2 | PHENYLPYRAZOLE INHIBITORS OF STORE OPERATED CALCIUM RELEASE | CALCIMEDICA INC. (US) | 2010-04-29 | — | — | WO | disclosed |