Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 11/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430288 | 0.89 | AURKA (0.39) | AURKAAURKBCHEK2HRH3PIK3CA | |
| SCHEMBL13430271 | 0.86 | AURKA (0.48) | AURKAAURKBRPS6KB1NTRK1CSF1R | |
| SCHEMBL13429734 | 0.86 | AURKA (0.53) | AURKAAURKBNTRK1CSF1RFLT3 | |
| SCHEMBL13430228 | 0.81 | AURKA (0.69) | AURKAAURKBNTRK1CSF1RFLT3 | |
| SCHEMBL13399860 | 0.81 | AURKA (0.68) | AURKAAURKBRPS6KB1CHEK2NTRK1 | |
| SCHEMBL13430281 | 0.80 | AURKA (0.49) | AURKAAURKBRPS6KB1NTRK1CSF1R | |
| SCHEMBL13429732 | 0.79 | AURKA (0.46) | AURKAAURKBNTRK1CSF1RFLT3 | |
| SCHEMBL13430286 | 0.79 | AURKA (0.41) | AURKAAURKBHRH3PIK3CAMTOR | |
| SCHEMBL13430283 | 0.77 | AURKA (0.54) | AURKAAURKBNTRK1CSF1RFLT3 | |
| SCHEMBL13399854 | 0.76 | AURKA (0.62) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036629-A2 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | WO | disclosed |