Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BCR | P11274 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430271 | 0.90 | AURKA (0.48) | AURKAHRH3AURKBPIK3CAMTOR | |
| SCHEMBL13430288 | 0.87 | AURKA (0.39) | AURKAHRH3AURKBPIK3CAMTOR | |
| SCHEMBL13430211 | 0.86 | AURKA (0.39) | AURKAHRH3AURKBPIK3CAMTOR | |
| SCHEMBL13399887 | 0.85 | AURKA (0.56) | AURKAHRH3AURKBKDR | |
| SCHEMBL13430277 | 0.82 | AURKA (0.52) | AURKAHRH3AURKBKDRFAAH | |
| SCHEMBL13399897 | 0.81 | AURKA (0.59) | AURKAHRH3AURKB | |
| SCHEMBL13430279 | 0.79 | AURKA (0.39) | AURKAHRH3AURKBKDRFAAH | |
| SCHEMBL13429851 | 0.79 | AURKA (0.47) | AURKAHRH3AURKBPIK3CAMTOR | |
| SCHEMBL13429734 | 0.78 | AURKA (0.53) | AURKAAURKBLCK | |
| SCHEMBL13430209 | 0.75 | AURKA (0.41) | AURKAHRH3AURKBPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765953-B2 | Compounds and methods for the treatment of pain and other diseases | AQUILUS PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2010036629-A2 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | WO | disclosed |