Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.39 |
| ▸ | USP7 | Q93009 | 1/20 | 0.36 |
| ▸ | USP47 | Q96K76 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.33 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | NRP1 | O14786 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13430209 | 0.87 | AURKA (0.41) | AURKAUSP7USP47AURKBHRH3 | |
| SCHEMBL13430286 | 0.86 | AURKA (0.41) | AURKAAURKBHRH3PIK3CAMTOR | |
| SCHEMBL13399899 | 0.86 | AURKA (0.52) | AURKAUSP7USP47AURKBHRH3 | |
| SCHEMBL13430271 | 0.86 | AURKA (0.48) | AURKAAURKBHRH3PIK3CAMTOR | |
| SCHEMBL13399905 | 0.83 | AURKA (0.56) | AURKAUSP7USP47AURKBHRH3 | |
| SCHEMBL13430212 | 0.83 | AURKA (0.53) | AURKAUSP7USP47AURKBPIK3CA | |
| SCHEMBL13430291 | 0.83 | AURKA (0.49) | AURKAUSP7USP47AURKBEGFR | |
| SCHEMBL13430208 | 0.80 | AURKA (0.37) | AURKAUSP7USP47AURKBEGFR | |
| SCHEMBL13430207 | 0.79 | AURKA (0.39) | AURKAEGFRERBB2 | |
| SCHEMBL13430288 | 0.76 | AURKA (0.39) | AURKAAURKBHRH3PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036629-A2 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | WO | disclosed |