Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 12/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13429732 | 0.91 | AURKA (0.46) | AURKAKDRAURKBEGFRCSF1R | |
| SCHEMBL13430229 | 0.84 | AURKA (0.56) | AURKAKDRAURKBEGFR | |
| SCHEMBL13399874 | 0.81 | AURKA (0.69) | AURKAKDRAURKBCSF1RRPS6KB1 | |
| SCHEMBL13430228 | 0.78 | AURKA (0.69) | AURKAKDRAURKBEGFRCSF1R | |
| SCHEMBL13430278 | 0.78 | AURKA (0.38) | AURKAKDRAURKBEGFRCSF1R | |
| SCHEMBL13430283 | 0.78 | AURKA (0.54) | AURKAKDRAURKBEGFRCSF1R | |
| SCHEMBL13430238 | 0.77 | AURKA (0.56) | AURKAAURKBEGFRCSF1R | |
| SCHEMBL13430271 | 0.76 | AURKA (0.48) | AURKAAURKBCSF1RRPS6KB1 | |
| SCHEMBL13430281 | 0.75 | AURKA (0.49) | AURKAAURKBCSF1RRPS6KB1 | |
| SCHEMBL13430255 | 0.75 | KDR (0.61) | AURKAKDREGFRFLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765953-B2 | Compounds and methods for the treatment of pain and other diseases | AQUILUS PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2010036629-A2 | FUSED MULTICYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2010-04-01 | — | — | WO | disclosed |