Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 11/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30571418 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL12897943 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL18269413 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL3221050 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL245092 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL13625375 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL14669553 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL245091 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL30571404 | 1.00 | HMGCR (0.74) | HMGCR | |
| SCHEMBL13764732 | 1.00 | HMGCR (0.74) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9150518-B2 | Process for preparing amorphous rosuvastatin calcium of impurities | LEK PHARMACEUTICALS, D.D. | 2015-10-06 | — | — | US | disclosed |
| US-20100069635-A1 | ROSUVASTATIN DEHYDROABIETYLAMINE SALT | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-03-18 | — | — | US | disclosed |
| US-20100069635-A1 | ROSUVASTATIN DEHYDROABIETYLAMINE SALT | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-03-18 | — | — | US | disclosed |
| US-20090111839-A1 | Process for Preparing Amorphous Rosuvastatin Calcium of Impurities | LEK PHARMACEUTICALS D.D. (SI) | 2009-04-30 | — | — | US | disclosed |
| US-20070255060-A1 | Process for the Manufacture of the Calcium Salt of Rosuvastatin (E)-7-'4-(4-Fluorophenyl)-6-Isopropyl-2-'Methyl (Methylsulfonyl) Amino ! Pyrmidin -5-Yl! (3R, 5S)-3,5-Dihydroxyhept-6-Enoic Acid and Crystalline Intermediates Thereof | ASTRAZENECA UK LIMITED (GB) | 2007-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069635-A1 | ROSUVASTATIN DEHYDROABIETYLAMINE SALT | HMGCR, DHCR7, PCSK9 | HMGCR 1/4885 |
| US-20090111839-A1 | Process for Preparing Amorphous Rosuvastatin Calcium of Impurities | HMGCR, PCSK9, CACNA2D1 | HMGCR 1/4885 |
| US-20070255060-A1 | Process for the Manufacture of the Calcium Salt of Rosuvastatin (E)-7-'4-(4-Fluorophenyl)-6-Isopropyl-2-'Methyl (Methylsulfonyl) Amino ! Pyrmidin -5-Yl! (3R, 5S)-3,5-Dihydroxyhept-6-Enoic Acid and Crystalline Intermediates Thereof | HMGCR, DHCR7, FADS2 | HMGCR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.