Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 17/20 | 1.00 |
| ▸ | PKLR | P30613 | 8/20 | 0.82 |
| ▸ | NPC1 | O15118 | 1/20 | 0.82 |
| ▸ | RAB9A | P51151 | 1/20 | 0.82 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12354636 | 0.96 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL1722758 | 0.91 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL15746503 | 0.87 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL1725568 | 0.87 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL1710857 | 0.85 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL1726834 | 0.85 | PKM (1.00) | PKMPKLRNPC1RAB9AMEN1 | |
| SCHEMBL30621219 | 0.84 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL30621218 | 0.84 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL12354635 | 0.84 | PKM (1.00) | PKMPKLRNPC1RAB9AHTT | |
| SCHEMBL29483533 | 0.83 | PKM (0.84) | PKMPKLRNPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010042867-A2 | ACTIVATORS OF HUMAN PYRUVATE KINASE | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-04-15 | — | — | WO | disclosed |