Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.54 |
| ▸ | PPARD | Q03181 | 4/20 | 0.54 |
| ▸ | PPARA | Q07869 | 4/20 | 0.54 |
| ▸ | DHFR | P00374 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.41 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3417597 | 0.88 | PPARA (0.56) | PPARGPPARDPPARADHFRKDM4E | |
| SCHEMBL13433236 | 0.86 | PPARA (0.56) | PPARGPPARDPPARADHFRKDM4E | |
| SCHEMBL13433235 | 0.83 | PPARD (0.52) | PPARGPPARDPPARADHFRKDM4E | |
| SCHEMBL6498808 | 0.80 | PPARA (0.44) | PPARGPPARDPPARAKDM4ENPC1 | |
| SCHEMBL3416603 | 0.78 | KDM4E (0.52) | PPARGPPARDPPARAKDM4ENPC1 | |
| SCHEMBL3415767 | 0.76 | PPARA (0.60) | PPARGPPARDPPARAKDM4ENPC1 | |
| SCHEMBL13461043 | 0.76 | KDM4E (0.51) | PPARGPPARDPPARAKDM4ENPC1 | |
| SCHEMBL3416622 | 0.76 | PPARA (0.46) | PPARGPPARDPPARAKDM4ERAB9A | |
| SCHEMBL3413742 | 0.75 | PPARA (0.58) | PPARGPPARDPPARAKDM4ENPC1 | |
| SCHEMBL3416671 | 0.74 | RAB9A (0.48) | PPARGPPARDPPARANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |
| US-7687664-B2 | Carboxylic acid derivative, a salt thereof or an ester of them, and medicament comprising it | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-03-30 | — | — | US | disclosed |