Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 6/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.42 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | MAT1A | Q00266 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.36 |
| ▸ | SPR | P35270 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1084497 | 0.87 | GBA1 (0.49) | GBA1PDE10AHSD11B1MAPTPDCD1LG2 | |
| SCHEMBL14406479 | 0.81 | MAT2A (0.42) | GBA1MAT2AMAT1AMAPTHIF1A | |
| SCHEMBL1084461 | 0.77 | CHEK2 (0.51) | GBA1PDE10AMAPTHIF1ACHEK2 | |
| SCHEMBL1084960 | 0.72 | CYP1A2 (0.51) | GBA1MAT2AMAT1AMAPTHIF1A | |
| SCHEMBL1084582 | 0.70 | POLB (0.42) | GBA1MAPTCHEK2TSHR | |
| SCHEMBL1084472 | 0.68 | SMAD3 (0.46) | GBA1MAPTCHEK2TSHRMAPK1 | |
| SCHEMBL1084931 | 0.68 | CHEK2 (0.53) | GBA1MAT2AMAT1AMAPTHIF1A | |
| SCHEMBL1084398 | 0.68 | MAPT (0.61) | GBA1MAPTHIF1ACYP1A2CYP3A4 | |
| SCHEMBL14406483 | 0.68 | GBA1 (0.51) | GBA1MAPTCYP1A2CYP3A4TSHR | |
| SCHEMBL11932265 | 0.66 | PDE10A (0.43) | GBA1PDE10ANAMPTSPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678802-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-03-16 | — | — | US | disclosed |