Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343063 | 0.83 | TP53 (0.52) | TP53GAALPAR1KCNMA1NPC1 | |
| SCHEMBL1342881 | 0.81 | TP53 (0.53) | TP53GAAKCNMA1NPC1RAB9A | |
| SCHEMBL1342697 | 0.81 | TP53 (0.53) | TP53GAALPAR1KCNMA1NPC1 | |
| SCHEMBL6701130 | 0.81 | TP53 (0.49) | TP53GAAKCNMA1NPC1RAB9A | |
| SCHEMBL1343141 | 0.80 | GAA (0.55) | TP53GAALPAR1KCNMA1NPC1 | |
| SCHEMBL6695210 | 0.80 | CCNE1 (0.39) | LPAR1CCNE1CDK2CDK5SMN1; SMN2 | |
| SCHEMBL2650328 | 0.80 | GAA (0.46) | TP53GAAKCNMA1NPC1RAB9A | |
| SCHEMBL1497603 | 0.79 | GAA (0.48) | TP53GAAKCNMA1NPC1RAB9A | |
| SCHEMBL1342128 | 0.79 | TP53 (0.42) | TP53GAALPAR1KCNMA1CCNE1 | |
| SCHEMBL6697170 | 0.79 | TP53 (0.42) | TP53GAALPAR1KCNMA1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |