Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 11/20 | 0.47 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.45 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3461531 | 0.89 | USP30 (0.56) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3461148 | 0.87 | ATR (0.51) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL14314423 | 0.82 | ATR (0.48) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3824904 | 0.82 | USP30 (0.56) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3462663 | 0.81 | ATR (0.51) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL13435411 | 0.80 | PIM1 (0.44) | ATRACVR1ACVR2ATGFBR2USP30 | |
| SCHEMBL3462072 | 0.80 | USP30 (0.53) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3461780 | 0.77 | ATR (0.48) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3460708 | 0.77 | ATR (0.53) | ATRACVR1ACVR2ATGFBR2TYRO3 | |
| SCHEMBL3461414 | 0.77 | ATR (0.55) | ATRACVR2ATGFBR2TYRO3USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7704995-B2 | Protein kinase modulators and methods of use | EXELIXIS, INC. (US) | 2010-04-27 | — | — | US | disclosed |