Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 2/20 | 0.41 |
| ▸ | CCR2 | P41597 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PYGL | P06737 | 7/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343722 | 1.00 | GPR183 (0.41) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1343198 | 0.92 | PYGL (0.41) | GPR183CCR2PYGLHRH3 | |
| SCHEMBL1343202 | 0.92 | PYGL (0.41) | GPR183CCR2PYGLHRH3 | |
| SCHEMBL1345062 | 0.92 | GPR183 (0.42) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1344625 | 0.92 | GPR183 (0.42) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1345065 | 0.92 | GPR183 (0.42) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1344626 | 0.92 | GPR183 (0.42) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1344624 | 0.92 | GPR183 (0.42) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1343943 | 0.91 | GPR183 (0.41) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL1343946 | 0.91 | GPR183 (0.41) | GPR183CCR2NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063042-B2 | Heterocyclic compounds | HOFFMANN-LA ROCHE INC. (US) | 2011-11-22 | — | — | US | disclosed |