Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 16/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557935 | 0.93 | HDAC1 (0.62) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13898504 | 0.91 | HDAC1 (0.60) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13453773 | 0.87 | HDAC1 (0.72) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13297079 | 0.86 | HDAC1 (0.64) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580291 | 0.85 | HDAC1 (0.69) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL19114229 | 0.85 | HDAC1 (0.76) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13297082 | 0.85 | HDAC1 (0.68) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL13437343 | 0.84 | HDAC1 (0.62) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL19114176 | 0.84 | HDAC1 (0.66) | HDAC1HDAC3HDAC6HDAC4 | |
| SCHEMBL15580284 | 0.83 | HDAC6 (0.78) | HDAC1HDAC3HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2030974-B1 | THIAZOLE NON-NUCLEOSIDE COMPOUNDS, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION AND THEIR USE AS ANTIVIRAL AGENTS | SHANGHAI INST MATERIA MEDICA (CN) | 2016-02-17 | — | — | EP | disclosed |
| US-8653115-B2 | Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-02-18 | — | — | US | disclosed |
| US-8653115-B2 | Heterocyclic non-nucleoside compounds, their preparation, pharmaceutical composition and their use as antiviral agents | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2014-02-18 | — | — | US | disclosed |
| US-20120264793-A1 | Pharmaceutical Use of 2',2-Bis-Thiazole Non-Nucleoside Compounds as Hepatitis C Virus Inhibitor | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2012-10-18 | — | — | US | disclosed |
| US-20100056569-A1 | Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-03-04 | — | — | US | disclosed |
| US-20100056569-A1 | Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2010-03-04 | — | — | US | disclosed |
| EP-2030974-A1 | HETEROCYCLIC NON-NUCLEOSIDE COMPOUNDS, THEIR PEPARATION, PHARMACEUTICAL COMPOSITION AND THEIR USE AS ANTIVIRAL AGENTS | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2009-03-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056569-A1 | Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents | TYMP, PNP, NUDT1 | HDAC1 598/4885HDAC3 977/4885HDAC6 1321/4885 |
| US-20120264793-A1 | Pharmaceutical Use of 2',2-Bis-Thiazole Non-Nucleoside Compounds as Hepatitis C Virus Inhibitor | HAVCR2, SLC29A2, SLC10A1 | HDAC1 3057/4885HDAC3 3543/4885HDAC6 1345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.