Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | HCK | P08631 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342258 | 0.86 | LCK (0.45) | LCKSMN1; SMN2KMT2AGAAMAPT | |
| SCHEMBL6693554 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2NPC1RAB9AKMT2AKDM4E | |
| SCHEMBL1342828 | 0.84 | SMN1; SMN2 (0.43) | LCKSMN1; SMN2RAB9AKMT2AALDH1A1 | |
| SCHEMBL1341394 | 0.84 | SMN1; SMN2 (0.42) | LCKSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL1342927 | 0.83 | LCK (0.42) | LCKSMN1; SMN2KMT2AGAAMAPT | |
| SCHEMBL1343084 | 0.83 | LCK (0.42) | LCKSMN1; SMN2KMT2AGAAMAPK14 | |
| SCHEMBL1343709 | 0.82 | LCK (0.42) | LCKSMN1; SMN2KMT2AGAAMAPT | |
| SCHEMBL1342476 | 0.81 | LCK (0.41) | LCKSMN1; SMN2MAPK14MAPK13EGFR | |
| SCHEMBL1342702 | 0.81 | MAPK14 (0.40) | SMN1; SMN2NPC1RAB9AMAPK14MAPK13 | |
| SCHEMBL1342321 | 0.80 | LCK (0.42) | LCKSMN1; SMN2MAPTMAPK14MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063081-B2 | N-(2-Phenoxyphenyl)-N'-(thiazol-2-yl)urea; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-11-22 | — | — | US | disclosed |
| US-7897628-B2 | {2-[3-(4-Methyl-2-[2-methypropoxy]phenyl)-ureido]-thiazol-4-yl}-acetic acid ethyl ester; glucokinase inhibitor; antidiabetic, hypoglycemic agent; activators of glucokinase | NOVO NORDISK A/S (DK) | 2011-03-01 | — | — | US | disclosed |