Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1342702 | 0.87 | MAPK14 (0.40) | SMN1; SMN2NPC1RAB9AMAPK14MAPK13 | |
| SCHEMBL1343774 | 0.85 | LCK (0.42) | SMN1; SMN2NPC1RAB9AALDH1A1MAPK14 | |
| SCHEMBL1342742 | 0.85 | OGA (0.41) | SMN1; SMN2NPC1RAB9AOGAMAPK14 | |
| SCHEMBL1342766 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AOGAALDH1A1 | |
| SCHEMBL1342719 | 0.84 | KDR (0.45) | OGANPSR1MAPK14MAPK13MAPT | |
| SCHEMBL1344039 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AOGAALDH1A1 | |
| SCHEMBL1341014 | 0.83 | SMN1; SMN2 (0.39) | SMN1; SMN2NPC1RAB9AOGAMAPK14 | |
| SCHEMBL1343232 | 0.83 | CNR1 (0.42) | SMN1; SMN2NPC1RAB9AOGAALDH1A1 | |
| SCHEMBL1341749 | 0.83 | SMN1; SMN2 (0.38) | SMN1; SMN2NPC1RAB9AOGAALDH1A1 | |
| SCHEMBL4470766 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2NPC1RAB9AOGAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | VTV THERAPEUTICS LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040122235-A1 | Aryl carbonyl derivatives as therapeutic agents | GCK, GCKR, PDK2 | SMN1; SMN2 2958/4885NPC1 2201/4885RAB9A 3353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.