Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.66 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.65 |
| ▸ | IKBKB | O14920 | 9/20 | 0.65 |
| ▸ | CHUK | O15111 | 2/20 | 0.64 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.63 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 2/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.55 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CCND3 | P30281 | 1/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3753567 | 0.87 | IKBKB (0.68) | PTGS2IKBKBCHUKMAPK8MAPK10 | |
| SCHEMBL3758490 | 0.83 | IKBKB (0.66) | PIK3CAPIK3CGPIK3CBIKBKBCHUK | |
| SCHEMBL3760443 | 0.82 | MAPK8 (0.57) | PTGS2IKBKBCHUKMAPK8MAPK10 | |
| SCHEMBL3760320 | 0.80 | IKBKB (0.59) | IKBKBCHUKMAPK8MAPK10CDK2 | |
| SCHEMBL3758611 | 0.80 | IKBKB (0.60) | IKBKBCHUKMAPK8MAPK10CDK2 | |
| SCHEMBL3516492 | 0.80 | IKBKB (0.72) | PIK3CAPIK3CGPIK3CBIKBKBCHUK | |
| SCHEMBL3754658 | 0.79 | MAPK8 (0.81) | IKBKBCHUKMAPK8MAPK10CDK2 | |
| SCHEMBL4375237 | 0.79 | JAK2 (0.81) | IKBKBCHUKMAPK8MAPK10CDK2 | |
| SCHEMBL3747898 | 0.79 | IKBKB (0.56) | IKBKBCHUKMAPK8MAPK10CDK2 | |
| SCHEMBL7467852 | 0.79 | PIK3CA (0.65) | PIK3CAPIK3CGPIK3CBMAPK8MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069417-A1 | NOVEL PHENYL(4-PHENYLPYRIMIDIN-2-YL)AMINE DERIVATIVES, THEIR PREPARATION, AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100069417-A1 | NOVEL PHENYL(4-PHENYLPYRIMIDIN-2-YL)AMINE DERIVATIVES, THEIR PREPARATION, AS MEDICAMENTS, PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | IKBKB, NFKBIA, IKBKE | PIK3CA 141/4885PIK3CG 160/4885PIK3CB 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.