Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.65 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.65 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 4/20 | 0.58 |
| ▸ | BCR | P11274 | 3/20 | 0.58 |
| ▸ | SRC | P12931 | 1/20 | 0.58 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7470313 | 0.84 | ABL1 (0.58) | PIK3CAPIK3CGPIK3CBNPC1MAPT | |
| SCHEMBL7470875 | 0.84 | PLK1 (0.63) | PIK3CAPIK3CGPIK3CBSYKABL1 | |
| SCHEMBL4903317 | 0.84 | ABL1 (0.70) | PIK3CAPIK3CGPIK3CBNPC1MAPT | |
| SCHEMBL4029958 | 0.84 | ABL1 (0.72) | PIK3CGNPC1MAPTRAB9AMAPK1 | |
| SCHEMBL16941489 | 0.84 | ABL1 (0.61) | PIK3CAPIK3CGPIK3CBABL1BCR | |
| SCHEMBL7461475 | 0.84 | ABL1 (0.76) | PIK3CAPIK3CGPIK3CBNPC1MAPT | |
| SCHEMBL7472770 | 0.83 | ABL1 (0.67) | PIK3CAPIK3CGPIK3CBABL1BCR | |
| SCHEMBL7468539 | 0.82 | ABL1 (0.71) | PIK3CAPIK3CGPIK3CBABL1BCR | |
| SCHEMBL7470657 | 0.82 | IKBKB (0.67) | PIK3CAPIK3CGPIK3CBNPC1MAPT | |
| SCHEMBL7465536 | 0.81 | ABL1 (0.54) | PIK3CAPIK3CGPIK3CBNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0233461-B2 | 4,5,6-Substituted-2-pyrimidinamines | AMERICAN CYANAMID CO (US) | 2002-05-29 | — | — | EP | disclosed |