Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 9/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | STK16 | O75716 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | DMPK | Q09013 | 1/20 | 0.31 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046449 | 0.84 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1KMT2AALDH1A1TP53 | |
| SCHEMBL14609804 | 0.78 | GABRA1 (0.40) | HSP90AA1HSP90AB1KMT2AALDH1A1MAPT | |
| SCHEMBL12046453 | 0.75 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1 | |
| SCHEMBL1148680 | 0.69 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1KMT2ABMPR1BSTK16 | |
| SCHEMBL2517374 | 0.67 | HSP90AA1 (0.33) | HSP90AA1HSP90AB1KMT2AALDH1A1 | |
| SCHEMBL14425300 | 0.66 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1KMT2AALDH1A1MAPT | |
| SCHEMBL1148835 | 0.65 | HSP90AA1 (0.38) | HSP90AA1HSP90AB1KMT2AALDH1A1MAPT | |
| SCHEMBL1148531 | 0.65 | CHEK1 (0.34) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL1147883 | 0.64 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL1148623 | 0.64 | HSP90AA1 (0.35) | HSP90AA1HSP90AB1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063083-B2 | Method for treating non-Hodgkin's lymphoma | SYNTA PHARMACEUTICALS CORP. (US) | 2011-11-22 | — | — | US | disclosed |
| US-8034834-B2 | Method for treating proliferative disorders with HSP90 inhibitors | SYNTA PHARMACEUTICALS CORP. (US) | 2011-10-11 | — | — | US | disclosed |