Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9313528 | 0.83 | ALDH1A1 (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL13403408 | 0.81 | EPHX2 (0.59) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL10730956 | 0.81 | EPHX2 (0.59) | EPHX2HDAC1HDAC6KDM4ENPC1 | |
| SCHEMBL13450859 | 0.81 | TSHR (0.64) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL13450864 | 0.80 | EPHX2 (0.69) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL16213688 | 0.77 | ALDH1A1 (0.53) | HDAC6ALDH1A1NPC1RAB9AMCHR1 | |
| SCHEMBL13450223 | 0.77 | EPHX2 (0.59) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL13403412 | 0.77 | NPC1 (0.64) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL13450252 | 0.77 | SMN1; SMN2 (0.52) | EPHX2HDAC1HDAC6KDM4EALDH1A1 | |
| SCHEMBL13403402 | 0.76 | EPHX2 (0.63) | EPHX2HDAC1HDAC6KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-B1 | TROPANE COMPOUNDS | EXELIXIS INC (US) | 2010-03-03 | — | — | EP | disclosed |