Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 14/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451779 | 0.83 | CCR2 (0.38) | CCR2P2RX7 | |
| SCHEMBL3165046 | 0.81 | PPARD (0.38) | CCR2 | |
| SCHEMBL13451778 | 0.79 | CCR2 (0.39) | CCR2 | |
| SCHEMBL14081575 | 0.69 | CCR2 (0.62) | CCR2 | |
| SCHEMBL14513598 | 0.66 | CCR2 (0.52) | CCR2 | |
| SCHEMBL13934251 | 0.66 | CCR2 (0.56) | CCR2 | |
| SCHEMBL4477732 | 0.61 | NPSR1 (0.32) | — | |
| SCHEMBL3625325 | 0.61 | PPARD (0.37) | CCR2P2RX7 | |
| SCHEMBL14369979 | 0.60 | PPARG (0.47) | — | |
| SCHEMBL3170282 | 0.59 | FFAR3 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615699-B1 | BENZOXAZINYL-AMIDOCYCLOPENTYL-HETEROCYCLIC MODULATORS OF CHEMOKINE RECEPTORS | MERCK SHARP & DOHME (US) | 2010-03-24 | — | — | EP | disclosed |