Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.74 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.74 |
| ▸ | HPGD | P15428 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.74 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.74 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.74 |
| ▸ | PDE4A | P27815 | 1/20 | 0.74 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.74 |
| ▸ | KCNA3 | P22001 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1344680 | 0.94 | CYP3A4 (0.76) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL12132138 | 0.88 | CYP1A1 (0.76) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL13920848 | 0.86 | CYP3A4 (0.81) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| Khellin SCHEMBL9655 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| Khellin SCHEMBL30839911 | 0.86 | CYP3A4 (1.00) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL3615938 | 0.83 | CYP1A1 (0.57) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL10300860 | 0.82 | CYP3A4 (0.74) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL13920849 | 0.81 | CYP3A4 (0.81) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL3608253 | 0.81 | CYP1A1 (0.64) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 | |
| SCHEMBL10300857 | 0.81 | CYP1A1 (0.71) | CYP3A4CYP1A1HPGDCYP1A2CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8063093-B2 | Derivatives of 5-(halo)alkanoyl-6-hydroxy- benozofuran, benzothiophene, or indole; autoimmune diseases; systemic lupus erythematosis, rheumatoid arthritis, multiple sclerosis and psoriasis, transplant rejection; antiproliferative, anticarcinogenic, antidiabetic, antiinflammatory and antiulcer agents | HARVEY ANDREW J (AU) | 2011-11-22 | — | — | US | disclosed |
| US-8063093-B2 | Derivatives of 5-(halo)alkanoyl-6-hydroxy- benozofuran, benzothiophene, or indole; autoimmune diseases; systemic lupus erythematosis, rheumatoid arthritis, multiple sclerosis and psoriasis, transplant rejection; antiproliferative, anticarcinogenic, antidiabetic, antiinflammatory and antiulcer agents | HARVEY ANDREW J (AU) | 2011-11-22 | — | — | US | disclosed |
| US-20080221194-A1 | Novel Potassium channel Blockers and Uses Thereof | HARVEY ANDREW J | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221194-A1 | Novel Potassium channel Blockers and Uses Thereof | KCNAB1, KCNB1, KCNMB1 | CYP3A4 2095/4885CYP1A1 1790/4885HPGD 3279/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.