Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.53 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.53 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.53 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.53 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28703062 | 0.84 | HRH3 (0.46) | DRD4HRH3 | |
| SCHEMBL12191227 | 0.80 | HRH3 (0.70) | DRD4HRH3 | |
| SCHEMBL17166482 | 0.78 | HRH3 (0.61) | DRD4CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL14061870 | 0.77 | DRD4 (0.52) | DRD4 | |
| SCHEMBL14061868 | 0.77 | DRD4 (0.52) | DRD4 | |
| SCHEMBL14061691 | 0.77 | DRD4 (0.52) | DRD4 | |
| SCHEMBL29483718 | 0.77 | DRD4 (0.65) | DRD4CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL21254395 | 0.75 | HTR2A (0.66) | DRD4CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL3167838 | 0.75 | HTR2A (0.66) | DRD4CHRNB2CHRNA4CHRNB1CHRNB4 | |
| SCHEMBL14208023 | 0.75 | HRH3 (0.68) | DRD4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| EP-1995241-B1 | Inhibitors of ion channels | ICAGEN INC (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-1995241-A1 | Inhibitors of ion channels | ICAgen, Incorporated (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2008118758-A1 | INHIBITORS OF ION CHANNELS | ICAGEN, INC. (GB) | 2008-10-02 | — | — | WO | disclosed |