Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 19/20 | 0.94 |
| ▸ | HDAC3 | O15379 | 16/20 | 0.94 |
| ▸ | HDAC2 | Q92769 | 14/20 | 0.94 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.94 |
| ▸ | NCOR2 | Q9Y618 | 7/20 | 0.94 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.94 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.94 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.94 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.94 |
| ▸ | UBA1 | P22314 | 1/20 | 0.94 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13468999 | 1.00 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL10314973 | 1.00 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL13453167 | 1.00 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL17263563 | 1.00 | HDAC1 (0.94) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL19872843 | 0.98 | HDAC1 (0.93) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL13453225 | 0.98 | HDAC1 (0.93) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| SCHEMBL15195524 | 0.98 | HDAC1 (0.93) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL23760411 | 0.97 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL2611944 | 0.97 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 | |
| Largazole SCHEMBL91139 | 0.97 | HDAC1 (1.00) | HDAC1HDAC3HDAC2HDAC6NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513290-B2 | Method for preparing largazole analogs and uses thereof | COLORADO STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2013-08-20 | — | — | US | disclosed |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264794-A1 | Method for Preparing Largazole Analogs and Uses Thereof | CYP51A1, ADPRS, LPXN | HDAC1 355/4885HDAC3 114/4885HDAC2 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.