Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 4/20 | 0.73 |
| ▸ | TUBB | P07437 | 4/20 | 0.73 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.73 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.73 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.73 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.73 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.73 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.73 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.73 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.73 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.73 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.73 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.73 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.73 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681548 | 1.00 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL682194 | 0.99 | TUBB4A (0.74) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14386277 | 0.94 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL682460 | 0.94 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13458650 | 0.94 | TUBB4A (0.73) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL13458460 | 0.92 | TUBB4A (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL682166 | 0.92 | TUBB4A (0.71) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL682415 | 0.90 | TUBB4A (0.80) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL22668792 | 0.89 | TUBB4A (0.79) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14386817 | 0.88 | TUBB4A (0.78) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010030582-A2 | NOSCAPINE AND NOSCAPINE ANALOGS AND THEIR USE IN TREATING INFECTIOUS DISEASES BY TUBULIN BINDING INHIBITION | EMORY UNIVERSITY (US) | 2010-03-18 | — | — | WO | disclosed |
| WO-2007133112-A1 | NOSCAPINE DERIVATIVES (VARIANTS), COMBINATORY AND FOCUSED LIBRARY, PHARMACEUTICAL COMPOSITION, METHODS FOR THE PRODUCTION (VARIANTS) AND THE USE THEREOF | IVASHCHENKO, ANDREY ALEXANDROVICH (RU) | 2007-11-22 | — | — | WO | disclosed |