Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.44 |
| ▸ | VEGFA | P15692 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL348893 | 0.86 | HRH3 (0.46) | HRH3ACKR3VEGFAEGLN1PIK3CD | |
| SCHEMBL3265007 | 0.85 | ACKR3 (0.49) | HRH3ACKR3VEGFAEGLN1PIK3CD | |
| SCHEMBL348818 | 0.82 | ACKR3 (0.51) | HRH3ACKR3VEGFAEGLN1PIK3CD | |
| SCHEMBL347902 | 0.82 | HRH3 (0.44) | HRH3ACKR3PIK3CD | |
| SCHEMBL6183439 | 0.73 | ACKR3 (0.45) | ACKR3VEGFAEGLN1GBA1 | |
| SCHEMBL2733360 | 0.72 | CYP3A4 (0.60) | — | |
| SCHEMBL1929314 | 0.72 | CNR2 (0.51) | ACKR3VEGFAEGLN1PIK3CDBAZ2A | |
| SCHEMBL28746914 | 0.72 | ACKR3 (0.47) | ACKR3VEGFAEGLN1CHRM2CHRM4 | |
| SCHEMBL21579067 | 0.71 | ACKR3 (0.49) | ACKR3VEGFAEGLN1PIK3CDCHRM2 | |
| SCHEMBL2734028 | 0.71 | ALDH1A1 (0.60) | ACKR3VEGFAEGLN1PIK3CDCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010025179-A1 | 1-(4-UREIDOBENZOYL)PIPERAZINE DERIVATIVES | N.V. ORGANON (NL) | 2010-03-04 | — | — | WO | disclosed |