SCHEMBL13458682

SCHEMBL13458682

c1ccc(-c2ccc(-c3cc(-c4ccc5cc6ccccc6cc5c4)nc4c3ccc3c(-c5ccc(-c6ccccc6)cc5)cc(-c5ccc6cc7ccccc7cc6c5)nc34)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 1/20 0.49
CYP1B1 Q16678 1/20 0.49
CYP1A2 P05177 3/20 0.44
ACACA Q13085 5/20 0.43
CYP2C19 P33261 2/20 0.41
ALDH1A1 P00352 2/20 0.41
CYP2C9 P11712 1/20 0.41
HPGD P15428 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CYP17A1 P05093 1/20 0.40
CYP19A1 P11511 1/20 0.40
CYP11B1 P15538 1/20 0.40
CYP11B2 P19099 1/20 0.40
ESR1 P03372 3/20 0.40
ESR2 Q92731 3/20 0.40
TP53 P04637 1/20 0.39
HIF1A Q16665 1/20 0.39
HSD17B10 Q99714 1/20 0.39
AURKA O14965 1/20 0.39
AURKB Q96GD4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13458815 0.95 CYP1A1 (0.54) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL29358046 0.93 CYP1A1 (0.56) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL184973 0.93 CYP1A1 (0.56) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL29373621 0.93 CYP1A1 (0.56) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL439445 0.92 CYP1A1 (0.58) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL440520 0.90 CYP1A1 (0.53) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL13458896 0.89 CYP1B1 (0.44) CYP1A1CYP1B1CYP1A2ACACAALDH1A1
SCHEMBL3693998 0.89 CYP1A1 (0.54) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL3693799 0.87 CYP1B1 (0.45) CYP1A1CYP1B1CYP1A2ACACACYP2C19
SCHEMBL13458693 0.87 CYP1A1 (0.56) CYP1A1CYP1B1CYP1A2ACACACYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2161272-A1 Phenanthrolines BASF SE (DE) 2010-03-10 EP disclosed