Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 5/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.62 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.53 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.52 |
| ▸ | CDK8 | P49336 | 4/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | ABL1 | P00519 | 3/20 | 0.52 |
| ▸ | CSF1R | P07333 | 2/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.52 |
| ▸ | BCR | P11274 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.52 |
| ▸ | STK25 | O00506 | 1/20 | 0.52 |
| ▸ | CIT | O14578 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13459938 | 0.91 | RET (0.66) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL13459593 | 0.87 | RET (0.64) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL13459818 | 0.84 | RET (0.64) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL13459587 | 0.82 | RET (0.55) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL13459841 | 0.81 | RET (0.58) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL13459579 | 0.80 | RIPK1 (0.79) | KDRRIPK1PDGFRBRAF1 | |
| SCHEMBL13459820 | 0.77 | RET (0.55) | RETKDRMKNK2RIPK1MKNK1 | |
| SCHEMBL2821099 | 0.77 | SRC (0.61) | RETKDRCDK8SRCABL1 | |
| SCHEMBL27927274 | 0.77 | ABL1 (0.60) | RETKDRCDK8SRCABL1 | |
| SCHEMBL16380144 | 0.75 | RET (0.63) | RETKDRMKNK2RIPK1MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010032986-A2 | NOVEL 5-(4-AMINOPHENYL)-ISOQUINOLINE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PRODUCTION METHOD FOR SAME, AND COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR PROPHYLAXIS AND TREATMENT OF MEDICAL CONDITION INDUCED BY RAF KINASE HYPERACTIVITY | 주식회사 이큐스팜 (KR) | 2010-03-25 | — | — | WO | disclosed |