Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 14/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | TNF | P01375 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8420164 | 0.87 | ADAM17 (0.49) | ADAM17MAPK1TNF | |
| SCHEMBL13948110 | 0.87 | ADAM17 (0.41) | ADAM17TNF | |
| SCHEMBL8420723 | 0.87 | ADAM17 (0.45) | ADAM17MAPK1TNF | |
| SCHEMBL8420455 | 0.87 | ADAM17 (0.41) | ADAM17MAPK1 | |
| SCHEMBL13462074 | 0.87 | ADAM17 (0.38) | ADAM17MAPK1TNF | |
| SCHEMBL8421968 | 0.87 | MAPK1 (0.42) | ADAM17MAPK1TNF | |
| SCHEMBL8420166 | 0.87 | ADAM17 (0.52) | ADAM17MAPK1TNF | |
| SCHEMBL8422048 | 0.86 | ADAM17 (0.48) | ADAM17MAPK1 | |
| SCHEMBL13462000 | 0.86 | ADAM17 (0.39) | ADAM17MAPK1TNF | |
| SCHEMBL8420286 | 0.86 | ADAM17 (0.40) | ADAM17MAPK1TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7687527-B2 | Compounds for the treatment of inflammatory disorders | SCHERING CORPORATION (US) | 2010-03-30 | — | — | US | disclosed |