Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 16/20 | 0.70 |
| ▸ | HDAC4 | P56524 | 12/20 | 0.70 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.70 |
| ▸ | HDAC7 | Q8WUI4 | 11/20 | 0.70 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.70 |
| ▸ | HDAC10 | Q969S8 | 11/20 | 0.70 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.70 |
| ▸ | HDAC6 | Q9UBN7 | 11/20 | 0.70 |
| ▸ | HDAC9 | Q9UKV0 | 11/20 | 0.70 |
| ▸ | HDAC5 | Q9UQL6 | 11/20 | 0.70 |
| ▸ | HDAC11 | Q96DB2 | 10/20 | 0.70 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521164 | 1.00 | HDAC1 (0.70) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1521160 | 1.00 | HDAC1 (0.70) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1521161 | 0.88 | HDAC1 (0.69) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1521166 | 0.88 | HDAC1 (0.69) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1520815 | 0.85 | HDAC1 (0.72) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1520819 | 0.85 | HDAC1 (0.72) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL12195777 | 0.85 | HDAC1 (0.51) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL13859920 | 0.85 | HDAC1 (0.72) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1520908 | 0.85 | HDAC1 (0.65) | HDAC1HDAC4HDAC3HDAC7HDAC2 | |
| SCHEMBL1520912 | 0.85 | HDAC1 (0.65) | HDAC1HDAC4HDAC3HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264159-A1 | SCREENING SYSTEM FOR MODULATORS OF HER2 MEDIATED TRANSCRIPTION AND HER2 MODULATORS IDENTIFED THEREBY | BUCK INSTITUTE FOR AGE RESEARCH (US) | 2012-10-18 | — | — | US | disclosed |