Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MMP1 | P03956 | 3/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 3/20 | 0.54 |
| ▸ | MMP8 | P22894 | 2/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | MMP2 | P08253 | 1/20 | 0.53 |
| ▸ | MMP9 | P14780 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8843464 | 0.88 | HTT (0.57) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL7080540 | 0.85 | HTT (0.62) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL5860960 | 0.85 | KMT2A (0.71) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL4022229 | 0.84 | ALDH1A1 (0.62) | HSD11B1KMT2AALDH1A1CA1CA2 | |
| SCHEMBL7382923 | 0.84 | ALDH1A1 (0.77) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL4592282 | 0.84 | HTT (0.70) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL6932007 | 0.83 | HTT (0.53) | HTTNPSR1MMP1HSD11B1KMT2A | |
| SCHEMBL17550651 | 0.82 | GAA (0.53) | MMP1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL2069531 | 0.82 | SMN1; SMN2 (0.52) | HSD11B1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL13299623 | 0.82 | PLCG1 (0.52) | MMP1KMT2AMEN1ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167469-B1 | SULFONYL-QUINOLINE DERIVATIVES | RICHTER GEDEON NYRT (HU) | 2012-08-15 | — | — | EP | disclosed |
| US-8063220-B2 | Sulfonyl-quinoline derivatives | RICHTER GEDEON NYRT. (HU) | 2011-11-22 | — | — | US | disclosed |
| EP-2167469-A1 | SULFONYL-QUINOLINE DERIVATIVES | Richter Gedeon NYRT (HU) | 2010-03-31 | — | — | EP | disclosed |
| US-20090270371-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT. (HU) | 2009-10-29 | — | — | US | disclosed |
| EP-1962849-B1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT (HU) | 2009-09-30 | — | — | EP | disclosed |
| US-20090042934-A1 | Sulfonyl-Quinoline Derivatives | RICHTER GEDEON NYRT. (HU) | 2009-02-12 | — | — | US | disclosed |
| WO-2008155588-A1 | SULFONYL-QUINOLINE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2008-12-24 | — | — | WO | disclosed |
| EP-1962849-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | Richter Gedeon NYRT (HU) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007072093-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | RICHTER GEDEON NYRT. (HU) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270371-A1 | QUINOLINE DERIVATIVES USEFUL IN THE TREATMENT OF MGLUR5 RECEPTOR-MEDIATED DISORDERS | GRM5, GRIK5, GRM1 | HTT 1107/4885NPSR1 158/4885MMP1 4883/4885 |
| US-20090042934-A1 | Sulfonyl-Quinoline Derivatives | GRM5, GRM1, GRIK5 | HTT 1053/4885NPSR1 146/4885MMP1 4758/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.