Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 11/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13465840 | 0.88 | PARP1 (0.42) | PARP1ROCK2MET | |
| SCHEMBL13275163 | 0.86 | MET (0.44) | PARP1MET | |
| SCHEMBL13449289 | 0.85 | PARP1 (0.40) | PARP1MGLLMET | |
| SCHEMBL13275450 | 0.85 | PARP1 (0.39) | PARP1 | |
| SCHEMBL13275245 | 0.85 | PARP1 (0.41) | PARP1MGLLMET | |
| SCHEMBL13274998 | 0.84 | PARP1 (0.40) | PARP1MET | |
| SCHEMBL12517949 | 0.84 | PARP1 (0.40) | PARP1MGLLMET | |
| SCHEMBL13465665 | 0.84 | MET (0.44) | PARP1MET | |
| SCHEMBL13275480 | 0.84 | PARP1 (0.40) | PARP1MGLLMET | |
| SCHEMBL13275332 | 0.83 | KDM4E (0.39) | PARP1MGLLMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2012-10-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264735-A1 | TYROSINE KINASE INHIBITORS | ABL1, MET, ERBB2 | PARP1 2307/4885ROCK2 209/4885MGLL 3742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.