Isoguanine

Isoguanine

SCHEMBL134676

Nc1[nH]c(=O)nc2nc[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.58
DPP4 P27487 1/20 0.50
GDA Q9Y2T3 2/20 0.48
PDPK1 O15530 1/20 0.48
ALDH1A1 P00352 1/20 0.47
CDK2 P24941 3/20 0.46
MAP3K5 Q99683 1/20 0.42
GRIA1 P42261 1/20 0.41
GRIA2 P42262 1/20 0.41
GRIA3 P42263 1/20 0.41
GRIA4 P48058 1/20 0.41
PI4KA P42356 2/20 0.41
PI4K2B Q8TCG2 2/20 0.41
PI4K2A Q9BTU6 2/20 0.41
PI4KB Q9UBF8 2/20 0.41
LMNA P02545 1/20 0.41
DRD3 P35462 1/20 0.41
XDH P47989 1/20 0.41
LRRK2 Q5S007 1/20 0.41
ABL1 P00519 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Isoguanine SCHEMBL8591972 0.98 PNP (0.56) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL10996060 0.92 PNP (0.50) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL20477064 0.89 PNP (0.79) PNPDPP4GDAALDH1A1GRIA1
Isoguanine SCHEMBL5885760 0.86 PNP (0.45) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL10380136 0.86 GDA (0.49) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL5074781 0.85 GRIA1 (0.45) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL22660143 0.84 PNP (0.43) PNPDPP4GDAPDPK1ALDH1A1
Isoguanine SCHEMBL11527542 0.79 PNP (0.39) PNPDPP4ALDH1A1LMNA
SCHEMBL6154676 0.77 PNP (0.49) PNPDPP4GDAPDPK1ALDH1A1
SCHEMBL11492860 0.77 PNP (0.49) PNPDPP4GDAPDPK1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 15646 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026106497-A2 FUNCTIONALIZED CIRCULAR RNA AND METHODS AND INTERMEDIATES FOR THEIR PRODUCTION SIEĆ BADAWCZA ŁUKASIEWICZ – PORT POLSKI OSRODEK ROZWOJU TECHNOLOGII (PL) 2026-05-21 WO claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
WO-2026090528-A2 CIRCULARLY STRUCTURED GUIDE RNAS FOR CRISPR GENOME EDITING UNIVERSITY OF MASSACHUSETTS (US) 2026-04-30 WO claimed
EP-4731784-A2 NICK INITIATED CYCLING EMISSION AND REPLACEMENT REACTION Seqonce Biosciences, Inc. (US) 2026-04-29 EP claimed
EP-4720304-A2 IMPROVED MODULAR PRIME EDITING WITH MODIFIED EFFECTORS AND TEMPLATES University of Massachusetts (US) 2026-04-08 EP claimed
EP-4713458-A2 COMPOSITIONS AND METHODS FOR REGULATING EXPRESSION OF ATXN2 Riboway Therapeutics, Inc. (US) 2026-03-25 EP claimed
EP-4709860-A1 COMPOSITIONS AND METHODS FOR IMPROVED GENOME EDITING WITH NME2CAS9 AND NME2-SMUCAS9 VARIANTS University of Massachusetts (US) 2026-03-18 EP claimed
EP-4703360-A1 INTERMEDIATE FOR PREPARING OLIGONUCLEOTIDE ANALOG OR SALT THEREOF, AND PREPARATION METHOD THEREFOR Shanghai Senhui Medicine Co., Ltd. (CN) 2026-03-04 EP claimed
WO-2001094638-A2 ASYNCHRONOUS PRIMED PCR APPLERA CORPORATION (US) 2001-12-13 WO claimed
US-6316228-B1 Efficient synthesis of nucleosides THE UNIVERSITY OF IOWA RESEARCH FOUNDATION 2001-11-13 US claimed
EP-1047705-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 2000-11-02 EP claimed
US-6127539-A Cyclopentenecarboxamide derivative, method for preparing the same and bicycloamide derivative used therein KURARAY CO., LTD. (JP) 2000-10-03 US claimed
US-6054568-A Nucleobase oligomers THE PERKIN-ELMER CORPORATION (US) 2000-04-25 US claimed
EP-0931090-A1 IMPROVED CHIMERIC OLIGONUCLEOTIDE VECTORS THE PERKIN-ELMER CORPORATION (US) 1999-07-28 EP claimed
WO-1999036429-A2 NUCLEOBASE OLIGOMERS THE PERKIN-ELMER CORPORATION (US) 1999-07-22 WO claimed
US-5817812-A Cyclopentenecarboxamide derivative, method for preparing the same and bicycloamide derivative used therein KURARAY CO., LTD. (JP) 1998-10-06 US claimed
WO-1998039353-A1 IMPROVED CHIMERIC OLIGONUCLEOTIDE VECTORS THE PERKIN-ELMER CORPORATION (US) 1998-09-11 WO claimed
WO-1998017781-A1 EFFICIENT SYNTHESIS OF NUCLEOSIDES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 1998-04-30 WO claimed