SCHEMBL6154676

SCHEMBL6154676

Nc1[nH]c(=S)nc2nc[nH]c12

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PNP P00491 1/20 0.49
PDPK1 O15530 1/20 0.48
GDA Q9Y2T3 1/20 0.48
CDK2 P24941 7/20 0.46
DPP4 P27487 1/20 0.46
ALDH1A1 P00352 3/20 0.44
XDH P47989 2/20 0.44
USP2 O75604 1/20 0.44
TP53 P04637 1/20 0.44
ADORA3 P0DMS8 1/20 0.44
HPGD P15428 1/20 0.44
PTGS1 P23219 1/20 0.44
MAPK3 P27361 1/20 0.44
HBB P68871 1/20 0.44
PAX8 Q06710 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAP3K5 Q99683 1/20 0.42
PI4KA P42356 2/20 0.41
PI4K2B Q8TCG2 2/20 0.41
PI4K2A Q9BTU6 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL7029727 0.98 PNP (0.47) PNPPDPK1GDACDK2DPP4
SCHEMBL29430969 0.77 PNP (0.41) PNPPDPK1GDACDK2DPP4
Isoguanine SCHEMBL134676 0.77 PNP (0.58) PNPPDPK1GDACDK2DPP4
Isoguanine SCHEMBL8591972 0.76 PNP (0.56) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL3701 0.73 PNP (0.62) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL1176577 0.73 PNP (0.62) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL28385604 0.72 PNP (0.61) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL27871419 0.72 PNP (0.61) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL27833745 0.72 PNP (0.61) PNPPDPK1GDACDK2DPP4
Thioguanine SCHEMBL28189108 0.72 PNP (0.61) PNPPDPK1GDACDK2DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912575-B1 PROCESSES FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY EURO CELTIQUE SA (LU) 2005-02-02 EP disclosed
EP-0916673-B1 6-Amino purine derivatives having PDE-IV inhibition activity EURO CELTIQUE SA (LU) 2003-01-29 EP disclosed
EP-1169321-A4 PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY EURO CELTIQUE SA (LU) 2002-10-30 EP disclosed
US-6413975-B1 DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA EURO-CELTIQUE, S.A. (LU) 2002-07-02 US disclosed
EP-1169321-A2 PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY Euro-Celtique S.A. (LU) 2002-01-09 EP disclosed
US-6319928-B1 ASTHMA, ALLERGIES, INFLAMMATION,DEPRESSION, DEMENTIA, ALZHEIMER'S DISEASE, VASCULAR AND MULTI-IN-FARCT DEMENTIA AND DISEASE CAUSED BY HUMAN IMMUNODEFICIENCY VIRUS TREATMENT; EFFICIENCY AND SELECTIVITY EURO-CELTIQUE, S.A. (LU) 2001-11-20 US disclosed
US-6310205-B1 Hypoxathine compounds EURO-CELTIQUE, S.A. (LU) 2001-10-30 US disclosed
US-6294541-B1 ENZYME INHIBITORS USING PURINE COMPOUNDS AS ANTIHISTAMINES EURO-CELTIQUE S.A. (LU) 2001-09-25 US disclosed
EP-0912575-A4 IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY EURO CELTIQUE SA (LU) 2001-04-25 EP disclosed
WO-2000059449-A2 PURINE DERIVATIVES HAVING PHOSPHODIESTERASE IV INHIBITION ACTIVITY EURO-CELTIQUE S.A. (LU) 2000-10-12 WO disclosed
EP-0916673-A1 6-Amino purine derivatives having PDE-IV inhibition activity Euroceltique S.A. (LU) 1999-05-19 EP disclosed
EP-0916672-A1 6-Amino purine derivatives having PDE-IV inhibition activity and intermediates Euroceltique S.A. (LU) 1999-05-19 EP disclosed
EP-0912575-A1 IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY Euro-Celtique S.A. (LU) 1999-05-06 EP disclosed
US-5864037-A Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity EURO-CELTIQUE, S.A. (LU) 1999-01-26 US disclosed
US-5744473-A USED FOR TREATING ALLERGIES, INFLAMMATION, ASTHMA, AND RHINITIS EURO-CELTIQUE, S.A. (LU) 1998-04-28 US disclosed
WO-1998011113-A1 NEW PDE IV INHIBITORS: 'BIS-COMPOUNDS' EURO-CELTIQUE, S.A. (LU) 1998-03-19 WO disclosed
WO-1997046561-A1 IMPROVED METHODS FOR THE SYNTHESIS OF CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITORY ACTIVITY EURO-CELTIQUE, S.A. (LU) 1997-12-11 WO disclosed
US-5561225-A Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages SOUTHERN RESEARCH INSTITUTE (US) 1996-10-01 US disclosed
EP-0705265-A1 NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY Euroceltique S.A. (LU) 1996-04-10 EP disclosed
WO-1995000516-A1 NOVEL CHEMICAL COMPOUNDS HAVING PDE-IV INHIBITION ACTIVITY EURO-CELTIQUE S.A. (LU) 1995-01-05 WO disclosed