SCHEMBL1346783

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL1346455	0.89	AURKA (0.42)	ALDH1A1MAPK14KDM4EMEN1KMT2A
	SCHEMBL1346722	0.86	KDR (0.53)	KDRFLT1BRAFGPR52MAPK14
	SCHEMBL1346582	0.86	KDR (0.57)	KDRFLT1ALDH1A1GAAL3MBTL1
	SCHEMBL1346251	0.85	KDR (0.44)	KDRFLT1ALDH1A1GAAL3MBTL1
	SCHEMBL1346626	0.83	KDR (0.50)	KDRFLT1BRAFGPR52MAPK14
	SCHEMBL1346568	0.81	KDR (0.50)	KDRFLT1L3MBTL1BRAFMAPK14
	SCHEMBL1347080	0.78	ALDH1A1 (0.55)	KDRALDH1A1GAAL3MBTL1BRAF
	SCHEMBL1346619	0.78	KDR (0.52)	KDRFLT1BRAFGPR52MAPK14
	SCHEMBL1345137	0.76	KDR (0.55)	KDRFLT1ALDH1A1BRAFMAPK14
	SCHEMBL1345025	0.76	PDCD1 (0.45)	KDRFLT1MAPK14KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.