Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679402 | 0.80 | KDM4E (0.57) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL19511938 | 0.77 | KDM4E (0.54) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL18044535 | 0.76 | KDM4E (0.57) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL197601 | 0.76 | KDM4E (0.57) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL27962153 | 0.76 | KDM4E (0.53) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL18044606 | 0.74 | KDM4E (0.54) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL19511810 | 0.70 | KDM4E (0.46) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL2675351 | 0.69 | KDM4E (1.00) | KDM4EMAPK1ALDH1A1HPGDLMNA | |
| SCHEMBL1137068 | 0.68 | KDM4E (0.54) | KDM4EMAPK1ALDH1A1HPGDNOTUM | |
| SCHEMBL12495098 | 0.68 | KDM4E (0.54) | KDM4EMAPK1ALDH1A1HPGDNOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1881976-B1 | SUBSTITUTED AMIDE DERIVATIVES AS PROTEIN KINASE INHIBITORS | AMGEN INC (US) | 2012-10-17 | — | — | EP | disclosed |