Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | NOTUM | Q6P988 | 6/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679241 | 0.86 | LMNA (0.57) | KDM4ENOTUMALDH1A1HPGDHSD17B10 | |
| SCHEMBL30209010 | 0.85 | NOTUM (0.57) | KDM4ENOTUMMAPK1ALDH1A1HPGD | |
| SCHEMBL21786023 | 0.85 | NOTUM (0.57) | KDM4ENOTUMMAPK1ALDH1A1HPGD | |
| SCHEMBL28430420 | 0.84 | KDM4E (0.63) | KDM4EMAPK1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL16474732 | 0.82 | KDM4E (0.56) | KDM4ENOTUMMAPK1ALDH1A1HPGD | |
| SCHEMBL679127 | 0.82 | MAPT (0.61) | KDM4EALDH1A1HPGDHSD17B10LMNA | |
| SCHEMBL19511938 | 0.81 | KDM4E (0.54) | KDM4ENOTUMMAPK1ALDH1A1HPGD | |
| SCHEMBL21786022 | 0.80 | ALDH1A1 (0.52) | KDM4ENOTUMALDH1A1HPGDLMNA | |
| SCHEMBL30208868 | 0.80 | ALDH1A1 (0.52) | KDM4ENOTUMALDH1A1HPGDLMNA | |
| SCHEMBL18044535 | 0.80 | KDM4E (0.57) | KDM4ENOTUMMAPK1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423366-B | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-111423366-B | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2022-05-27 | — | — | CN | disclosed |
| CN-111423366-A | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2020-07-17 | — | — | CN | disclosed |
| CN-111423366-A | Preparation method of pirfenidone | 山东汇海医药化工有限公司 | 2020-07-17 | — | — | CN | disclosed |
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |
| US-8030302-B2 | Amidophenoxyindazoles useful as inhibitors of c-Met | ELI LILLY AND COMPANY (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100022529-A1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | ELI LILLY AND COMPANY | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100022529-A1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | MET, MYCBP, MYC | KDM4E 1545/4885NOTUM 3269/4885MAPK1 2143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.