Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 5/20 | 0.35 |
| ▸ | LCK | P06239 | 5/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19749271 | 0.78 | IDO1 (0.55) | IDO1TDO2GABRA5LCKCHEK1 | |
| SCHEMBL20110112 | 0.74 | IDO1 (0.69) | IDO1TDO2LCK | |
| SCHEMBL19749307 | 0.72 | IDO1 (0.67) | IDO1TDO2LCK | |
| SCHEMBL3356849 | 0.71 | GABRA5 (0.50) | IDO1TDO2GABRA5LCKGABRA1 | |
| SCHEMBL13281959 | 0.68 | IDO1 (1.00) | IDO1TDO2LCK | |
| SCHEMBL19749323 | 0.68 | IDO1 (1.00) | IDO1TDO2LCK | |
| SCHEMBL13281956 | 0.68 | IDO1 (1.00) | IDO1TDO2LCK | |
| SCHEMBL13281957 | 0.68 | IDO1 (1.00) | IDO1TDO2LCK | |
| SCHEMBL22200847 | 0.67 | IDO1 (0.42) | IDO1TDO2GABRA5LCKGABRA1 | |
| SCHEMBL20621275 | 0.67 | IDO1 (0.42) | IDO1TDO2GABRA5LCKGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012142237-A1 | FUSED IMIDAZOLE DERIVATIVES USEFUL AS IDO INHIBITORS | NEWLINK GENETICKS CORPORATION (US) | 2012-10-18 | — | — | WO | disclosed |