Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 13/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11987212 | 0.90 | SIRT1 (0.42) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL219651 | 0.80 | F2RL3 (0.46) | SIRT1 | |
| SCHEMBL13470774 | 0.80 | TP53 (0.46) | SIRT1MAPK8EGFRAKT1AKT2 | |
| SCHEMBL222169 | 0.79 | SIRT1 (0.52) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL221866 | 0.76 | SIRT1 (0.50) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL962137 | 0.76 | SIRT1 (0.40) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL4610482 | 0.76 | SIRT1 (0.65) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL4695257 | 0.76 | SIRT1 (0.55) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL3503103 | 0.76 | SIRT1 (0.49) | SIRT1SMN1; SMN2ARCHRM2ADRA2A | |
| SCHEMBL13077858 | 0.72 | SIRT1 (0.33) | SIRT1ARCHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |