Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 14/20 | 0.67 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.67 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.67 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740359 | 0.87 | SIRT1 (0.74) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740378 | 0.86 | SIRT1 (0.64) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL14608035 | 0.86 | SIRT1 (0.73) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740410 | 0.85 | SIRT1 (0.72) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740405 | 0.84 | SIRT1 (0.61) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL13083476 | 0.84 | SIRT1 (0.63) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740409 | 0.83 | SIRT1 (0.69) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740335 | 0.82 | SIRT1 (0.86) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740334 | 0.81 | SIRT1 (0.85) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 | |
| SCHEMBL2740400 | 0.81 | SIRT1 (0.66) | SIRT1CHRM2ADRA2ACHRM1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |