Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 14/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | THRB | P10828 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2624625 | 0.92 | MAPT (0.70) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL1075389 | 0.85 | MAPT (0.80) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12963235 | 0.81 | MAPT (0.67) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL2624629 | 0.80 | MAPT (0.71) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12963229 | 0.79 | MAPT (0.71) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL2247443 | 0.77 | SMN1; SMN2 (1.00) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12963206 | 0.77 | MAPT (0.65) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12963459 | 0.76 | ALDH1A1 (0.62) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL21674646 | 0.76 | MAPT (0.64) | MAPTSMN1; SMN2KDM4ENPC1RAB9A | |
| SCHEMBL12963245 | 0.75 | MAPT (0.68) | MAPTSMN1; SMN2KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |