Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2740319 | 0.92 | CHRM3 (0.49) | MAPTTP53ACKR3SIRT1MCHR1 | |
| SCHEMBL2740387 | 0.92 | MAPT (0.46) | MAPTTP53SIRT1MCHR1NPC1 | |
| SCHEMBL12342558 | 0.87 | MCHR1 (0.51) | MAPTTP53TRPV1MCHR1HTR2C | |
| SCHEMBL13470807 | 0.86 | OPRM1 (0.47) | MAPTTP53ACKR3HDAC1 | |
| SCHEMBL12342567 | 0.85 | MCHR1 (0.47) | MAPTTP53MCHR1HTR2CHDAC1 | |
| SCHEMBL12342717 | 0.83 | MCHR1 (0.46) | MAPTTP53MCHR1HTR2CHDAC1 | |
| SCHEMBL12342702 | 0.82 | MCHR1 (0.48) | TRPV1MCHR1HTR2CHDAC1 | |
| SCHEMBL12342551 | 0.80 | HDAC1 (0.49) | MAPTTP53SIRT1MCHR1HTR2C | |
| SCHEMBL12342542 | 0.80 | HDAC1 (0.49) | MAPTTP53MCHR1HTR2CHDAC1 | |
| SCHEMBL12342651 | 0.79 | NTRK3 (0.49) | MAPTTP53ACKR3SIRT1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910362-B1 | IMIDAZOPYRIDINE DERIVATIVES AS SIRTUIN MODULATING AGENTS | SIRTRIS PHARMACEUTICALS INC (US) | 2012-10-17 | — | — | EP | disclosed |