Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 13/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20699721 | 0.93 | HMGCR (0.48) | HMGCR | |
| SCHEMBL2368045 | 0.92 | HMGCR (0.47) | HMGCR | |
| SCHEMBL7952917 | 0.91 | HMGCR (0.49) | HMGCR | |
| SCHEMBL1978777 | 0.91 | HMGCR (0.48) | HMGCR | |
| SCHEMBL3167877 | 0.89 | HMGCR (0.47) | HMGCR | |
| SCHEMBL3964715 | 0.89 | HMGCR (0.47) | HMGCR | |
| SCHEMBL14243679 | 0.89 | HMGCR (0.47) | HMGCR | |
| SCHEMBL20699715 | 0.89 | HMGCR (0.48) | HMGCR | |
| Methylamine SCHEMBL3171804 | 0.89 | HMGCR (0.46) | HMGCR | |
| SCHEMBL22582724 | 0.88 | HMGCR (0.48) | HMGCRALDH1A1CYP3A4PDE6DNR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2373609-B1 | USE OF AMPHIPHILIC COMPOUNDS FOR CONTROLLED CRYSTALLIZATION OF STATINS AND STATIN INTERMEDIATES | KRKA D D NOVO MESTO (SI) | 2013-10-16 | — | — | EP | claimed |
| EP-2788342-B1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARM NL BV (NL) | 2018-01-24 | — | — | EP | disclosed |
| EP-2788341-B1 | PROCESS FOR THE PREPARATION OF A THIOPRECURSOR FOR STATINS | DSM SINOCHEM PHARM NL BV (NL) | 2017-04-05 | — | — | EP | disclosed |
| EP-2665722-B1 | PROCESS FOR THE PREPARATION OF DIOL SULFONES | DSM SINOCHEM PHARM NL BV (NL) | 2016-08-17 | — | — | EP | disclosed |
| US-9150562-B2 | Process for the preparation of diol sulfones | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-10-06 | — | — | US | disclosed |
| US-9126975-B2 | Process for the preparation of statins in the presence of base | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-09-08 | — | — | US | disclosed |
| EP-2665723-B1 | PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE | DSM SINOCHEM PHARM NL BV (NL) | 2015-07-22 | — | — | EP | disclosed |
| EP-2665721-B1 | METHYLTETRAZOLE SULFIDES AND SULFONES | DSM SINOCHEM PHARM NL BV (NL) | 2015-07-08 | — | — | EP | disclosed |
| US-8987478-B2 | Process for the preparation of a statin precursor | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2015-03-24 | — | — | US | disclosed |
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2014-12-04 | — | — | US | disclosed |
| US-20130303779-A1 | PROCESS FOR THE PREPARATION OF DIOL SULFONES | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-11-14 | — | — | US | disclosed |
| US-20130296561-A1 | PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE | DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V. (NL) | 2013-11-07 | — | — | US | disclosed |
| US-8063213-B2 | Reacting (1-6C)alkyl ester of (E)-(6-{2-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl}(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl) acetic acid with hydrochloric acid, salt formation with sodium or potassium hydroxide, basification, desolventization, salt exchange | ASTRAZENECA UK LIMITED (GB) | 2011-11-22 | — | — | US | disclosed |
| WO-2011104725-A2 | HMG-COA REDUCTASE INHIBITORS AND PROCESS FOR THE PREPARATION THEREOF | CADILA HEALTHCARE LIMITED (IN) | 2011-09-01 | — | — | WO | disclosed |
| US-20080221323-A1 | Production of Rosuvastatin Calcium Salt | ASTRAZENECA UK LIMITED (GB) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140357864-A1 | PROCESS FOR THE PREPARATION OF A STATIN PRECURSOR | HMGCR, PCSK9, DHCR7 | HMGCR 1/4885ALDH1A1 1385/4885CYP3A4 70/4885 |
| US-20130303779-A1 | PROCESS FOR THE PREPARATION OF DIOL SULFONES | STS, DHCR7, TST | HMGCR 5/4885ALDH1A1 927/4885CYP3A4 24/4885 |
| US-20080221323-A1 | Production of Rosuvastatin Calcium Salt | HMGCR, INPP5D, INPPL1 | HMGCR 1/4885ALDH1A1 2489/4885CYP3A4 2136/4885 |
| US-20130296561-A1 | PROCESS FOR THE PREPARATION OF STATINS IN THE PRESENCE OF BASE | CYP4A11, HMGCR, PCSK9 | HMGCR 2/4885ALDH1A1 1061/4885CYP3A4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.