TST

Thiosulfate sulfurtransferase · Q16762 · TST on Sugi Atlas →

38,058 patent compounds predicted against TST, 29,421 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Riboflavin (SCHEMBL7706)	1.00	2/20
Riboflavin (SCHEMBL7707)	1.00	2/20
Homidium (SCHEMBL20520)	1.00	2/20
Menadione (SCHEMBL25970)	1.00	2/20
Homidium (SCHEMBL27609)	1.00	2/20
Plumbagin (SCHEMBL34186)	1.00	2/20
Evans Blue Free Acid (SCHEMBL103701)	1.00	2/20
Riboflavin 5'-Phosphate (SCHEMBL26122)	0.98	2/20
Riboflavin (SCHEMBL246757)	0.96	2/20
Riboflavin (SCHEMBL50096)	0.92	2/20
Chicago Sky Blue (SCHEMBL93506)	0.90	2/20
Riboflavin 5'-Phosphate (SCHEMBL195609)	0.88	2/20
Riboflavin (SCHEMBL50154)	0.87	2/20
Riboflavin (SCHEMBL182060)	0.84	2/20
Riboflavin (SCHEMBL232228)	0.84	2/20
Riboflavin 5'-Phosphate (SCHEMBL41133)	0.83	2/20
Riboflavin 5'-Phosphate (SCHEMBL190079)	0.83	2/20
Homidium (SCHEMBL80118)	0.81	2/20
SCHEMBL50097	0.74	2/20
SCHEMBL50155	0.73	2/20

Clinical trials — most relevant to TST by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Comparison of Quantiferon-TB Gold Assay With Tuberculin Skin Testing in Patients With Chronic Liver Disease	PHASE4	COMPLETED
Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy	PHASE3	COMPLETED
Assessment of Efficacy and Safety of Thioctic Acid in the Oral Treatment of Symptomatic Diabetic Neuropathy (SYDNEY 2)	PHASE3	COMPLETED
Comparison of Diagnostic Performance of C-Tb to QuantiFERON®-TB, in Combination With a Safety Assessment of C-Tb vs Tuberculin PPD RT23 SSI	PHASE3	COMPLETED
Double-blind Trial of Sodium Thiosulfate for the Treatment of Pain Associated With Calcific Uremic Arteriolopathy	PHASE3	WITHDRAWN
Safety and Tolerability of Sodium Thiosulfate in Patients With an ACS Undergoing CAG Via Trans-radial Approach.	PHASE1/PHASE2	COMPLETED
A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis	PHASE2	COMPLETED
Effects of Broccoli Sprout Extract on Allergy Rhinitis	PHASE2	COMPLETED
Selumetinib Sulfate in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer With KRAS G12R Mutations	PHASE2	COMPLETED
Evaluation of Thiosulfate in End Stage Renal Disease and Kidney Transplantation	PHASE1	COMPLETED
Pharmacokinetic Study to Investigate the Bioavailability and Tolerability of 3 Oral Formulations of Sodium Thiosulfate	PHASE1	WITHDRAWN
Safety of Cultured Allogeneic Adult Umbilical Cord Derived Mesenchymal Stem Cells for Ovarian Failure	PHASE1	WITHDRAWN
Effect of Sulfur Amino Acid Depletion and Acetaminophen on Plasma Glutatione	nan	COMPLETED
Evaluation of Mitochondrial Enzyme Activity in Cesarean Section Patients	nan	UNKNOWN
The Usefulness of Interferon-γ Release Assays and Tuberculin Skin Test for Detection of Latent Tuberculosis Infection	nan	UNKNOWN
Broccoli and Vascular Health Study	nan	COMPLETED
Effects of Preoperative Oral Carbohydrate Loading on Maternal Thiol-disulfide Homeostasis	nan	COMPLETED
Metabolic Analysis in Human Sulfur Amino Acid Deficiency	nan	COMPLETED
Effects of TIVA and Inhalation Anesthesia on Oxidative Stress Factors During Hypotensive Anesthesia	nan	COMPLETED
Dietary Effects of Sulfur Amino Acids	nan	COMPLETED
Thiol/Disulphide Homeostasis in Unexplained Infertility	nan	COMPLETED
Oral and Gut Microbiota Changes During Long-term Fasting in Humans	nan	COMPLETED
Low Flow and High Flow Anesthesia on Thiol-Disulfide Homeostasis and IMA in Laparoscopic Cholecystectomy Surgery	nan	COMPLETED
Mechanisms of Response to Diesel Exhaust in Subjects With Asthma	nan	WITHDRAWN
Macrophage Migration Inhibitory Factor (MIF)- Cardiac Surgery	nan	COMPLETED
The Conversion of ENcapsulated GlucorAphanin, Gut Microbiota Phylogeny and gEnotype Study (ENGAGE)	nan	COMPLETED
External Nitric Oxide Measurement Through SNO Degradation	nan	ENROLLING_BY_INVITATION
C-TST for Diagnosis of Latent Mycobacterium Tuberculosis Infection in Indonesia	nan	COMPLETED
Dietary Interventions During Living Kidney Donations	nan	RECRUITING
The Effects of Dexmedetomidine on Thiol/Disulphide Homeostasis in Coronary Bypass Surgery	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a TST binder may also engage these)

Protein	Name	Similarity
P00586	—	1.000	P00586 →
P52196	—	0.997	P52196 →
P46635	—	0.997	P46635 →
P24329	—	0.996	P24329 →
P97532	—	0.982	P97532 →
P25324	—	0.982	P25324 →
MPST	3-mercaptopyruvate sulfurtransferase	0.980	landscape →
Q99J99	—	0.964	Q99J99 →
O95671	—	0.928	O95671 →
Q8HZJ0	—	0.927	Q8HZJ0 →
Q92056	—	0.927	Q92056 →
P10950	—	0.925	P10950 →
Q5I0D5	—	0.925	Q5I0D5 →
B1WC37	—	0.924	B1WC37 →
Q91WC3	—	0.923	Q91WC3 →
Q8K183	—	0.923	Q8K183 →
Q9D7I5	—	0.923	Q9D7I5 →
Q9DAT5	—	0.921	Q9DAT5 →
Q96RR1	—	0.921	Q96RR1 →
Q5BJJ5	—	0.921	Q5BJJ5 →
KHK	Ketohexokinase	0.921	landscape →
ACSL6	Long-chain-fatty-acid--CoA ligase 6	0.921	landscape →
P46597	—	0.920	P46597 →
O35331	—	0.919	O35331 →
Q5ZKW0	—	0.919	Q5ZKW0 →
Q9H0R4	—	0.919	Q9H0R4 →
O46560	—	0.919	O46560 →
Q8NHP1	—	0.918	Q8NHP1 →
Q8N0X4	—	0.918	Q8N0X4 →
Q96NN9	—	0.918	Q96NN9 →