Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.76 |
| ▸ | AR | P10275 | 6/20 | 0.76 |
| ▸ | LMNA | P02545 | 5/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.76 |
| ▸ | ESR1 | P03372 | 4/20 | 0.76 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.76 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.76 |
| ▸ | MEN1 | O00255 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.76 |
| ▸ | SHBG | P04278 | 3/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.76 |
| ▸ | POLB | P06746 | 1/20 | 0.76 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.64 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4106879 | 0.89 | PGR (0.66) | PGRARLMNASLC6A4CYP3A4 | |
| SCHEMBL4111788 | 0.89 | PGR (0.66) | PGRARLMNASLC6A4CYP3A4 | |
| SCHEMBL13334827 | 0.87 | CYP3A4 (0.70) | PGRARLMNASLC6A4CYP3A4 | |
| SCHEMBL25594418 | 0.87 | PGR (0.76) | PGRARLMNASLC6A4CYP3A4 | |
| SCHEMBL14191198 | 0.87 | PGR (0.76) | PGRARLMNASLC6A4CYP3A4 | |
| Levonorgestrel SCHEMBL22364344 | 0.86 | PGR (1.00) | PGRARLMNASLC6A4CYP3A4 | |
| Norgestrel SCHEMBL4319113 | 0.86 | PGR (1.00) | PGRARLMNASLC6A4CYP3A4 | |
| Levonorgestrel SCHEMBL21741985 | 0.86 | PGR (1.00) | PGRARLMNASLC6A4CYP3A4 | |
| Levonorgestrel SCHEMBL20927506 | 0.86 | PGR (1.00) | PGRARLMNASLC6A4CYP3A4 | |
| Levonorgestrel SCHEMBL825664 | 0.86 | PGR (1.00) | PGRARLMNASLC6A4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2178899-B1 | 17BETA-CYANO-18A-HOMO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE | BAYER IP GMBH (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2008151745-A1 | 17BETA-CYANO-18A-HOMO-19-NOR-ANDROST-4-ENE DERIVATIVE, USE THEREOF AND MEDICAMENTS CONTAINING SAID DERIVATIVE | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-12-18 | — | — | WO | disclosed |