Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.61 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13493143 | 0.84 | HTR7 (0.50) | DRD2DRD3HTR7HTR2A | |
| SCHEMBL13496856 | 0.84 | HTR7 (0.50) | DRD2DRD3HTR7HTR2A | |
| SCHEMBL8057138 | 0.84 | DRD3 (0.58) | DRD2DRD3HTR7HTR2A | |
| SCHEMBL4519876 | 0.77 | KCNH2 (1.00) | KCNH2HTR7 | |
| SCHEMBL11161100 | 0.76 | KCNH2 (0.80) | KCNH2DRD2DRD3HTR7HTR2A | |
| SCHEMBL13711972 | 0.75 | KCNH2 (0.84) | KCNH2DRD2HTR7HRH1 | |
| SCHEMBL3198969 | 0.74 | KCNH2 (0.72) | KCNH2DRD2DRD4DRD3HTR7 | |
| SCHEMBL15118465 | 0.74 | EGLN1 (0.50) | DRD2HTR2A | |
| SCHEMBL13475441 | 0.74 | KDM1A (0.45) | HRH1 | |
| SCHEMBL11353566 | 0.73 | KCNH2 (0.80) | KCNH2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2151777-A1 | Method for screening of 5HT7 receptor ligands based on a new pharmacophore model and a descriptor's profile filter | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2010-02-10 | — | — | EP | disclosed |