Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | RHEB | Q15382 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2839683 | 0.84 | CDKN1A (0.56) | TNKSALDH1A1MAPTGAAKDM4E | |
| SCHEMBL2843704 | 0.84 | KDM4E (0.50) | TNKSALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2843024 | 0.82 | TMIGD3 (0.46) | TNKSALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2837248 | 0.82 | ALDH1A1 (0.61) | ALDH1A1GAAKDM4EHPGDHSD17B10 | |
| SCHEMBL2838028 | 0.81 | ALDH1A1 (0.57) | ALDH1A1MAPTKDM4EHPGDHSD17B10 | |
| SCHEMBL13475914 | 0.80 | TMIGD3 (0.45) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL2833833 | 0.80 | FGFR1 (0.52) | ALDH1A1MAPTKDM4EHPGDSMN1; SMN2 | |
| SCHEMBL2837355 | 0.79 | BRD4 (0.55) | TNKSALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL2837954 | 0.78 | TNKS (0.47) | TNKSALDH1A1MAPTKDM4EHPGD | |
| SCHEMBL2839494 | 0.77 | ALDH1A1 (0.43) | ALDH1A1MAPTGAAKDM4CKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662814-B2 | 4-(4-Ethylpiperazin-1-yl)-5-methyl-2-phenylthieno[2,3-d]pyrimidine-6-carbonitrile; asthma, atopic dermatitis, chronic obstructive pulmonary disease, Crohn's disease, type I and type II diabetes, lymphoid leukemia and other forms of cancer, multiple sclerosis and autoimmune diseases | LABORATORIOS ALMIRALL, S.A. (ES) | 2010-02-16 | — | — | US | disclosed |