Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500655 | 0.83 | HSP90AB1 (0.50) | HSP90AA1HSP90AB1 | |
| SCHEMBL13477696 | 0.83 | HSP90AB1 (0.45) | HSP90AA1HSP90AB1 | |
| SCHEMBL13477697 | 0.80 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1 | |
| SCHEMBL13639271 | 0.80 | HSP90AB1 (0.43) | HSP90AA1HSP90AB1 | |
| SCHEMBL14286490 | 0.76 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL501271 | 0.76 | HSP90AB1 (0.51) | HSP90AA1HSP90AB1 | |
| SCHEMBL13477745 | 0.75 | HSP90AA1 (0.44) | HSP90AA1HSP90AB1 | |
| SCHEMBL13477744 | 0.73 | HSP90AB1 (0.36) | HSP90AA1HSP90AB1 | |
| SCHEMBL13477765 | 0.72 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1 | |
| SCHEMBL3703258 | 0.71 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017545-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARAMCEUTICALS CORP. (US) | 2010-02-11 | — | — | WO | disclosed |