Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 18/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 18/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13477690 | 0.83 | HSP90AA1 (0.39) | HSP90AB1HSP90AA1 | |
| SCHEMBL13639271 | 0.82 | HSP90AB1 (0.43) | HSP90AB1HSP90AA1 | |
| SCHEMBL3417666 | 0.80 | HSP90AB1 (0.58) | HSP90AB1HSP90AA1 | |
| SCHEMBL14286490 | 0.79 | HSP90AA1 (0.44) | HSP90AB1HSP90AA1 | |
| SCHEMBL13477745 | 0.77 | HSP90AA1 (0.44) | HSP90AB1HSP90AA1 | |
| SCHEMBL13477765 | 0.74 | HSP90AA1 (0.42) | HSP90AB1HSP90AA1 | |
| SCHEMBL24453198 | 0.72 | HSP90AB1 (0.50) | HSP90AB1HSP90AA1 | |
| SCHEMBL12844746 | 0.72 | HSP90AA1 (0.41) | HSP90AB1HSP90AA1 | |
| SCHEMBL16690631 | 0.72 | HSP90AB1 (0.49) | HSP90AB1HSP90AA1 | |
| SCHEMBL929652 | 0.71 | HSP90AA1 (0.48) | HSP90AB1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010017545-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARAMCEUTICALS CORP. (US) | 2010-02-11 | — | — | WO | disclosed |