SCHEMBL13477709

SCHEMBL13477709

C=C(c1cc(C(C)C)c(O)cc1O)N(C(=O)NN)c1ccc2c(ccn2CCNC(=O)CCCN2C(=O)CCC2=O)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.35
MTNR1B P49286 3/20 0.35
HDAC3 O15379 11/20 0.33
HDAC1 Q13547 11/20 0.33
HDAC6 Q9UBN7 11/20 0.33
HDAC8 Q9BY41 10/20 0.33
HSP90AA1 P07900 9/20 0.33
HDAC2 Q92769 8/20 0.33
HDAC11 Q96DB2 8/20 0.33
HDAC5 Q9UQL6 8/20 0.33
HDAC7 Q8WUI4 7/20 0.33
HDAC10 Q969S8 7/20 0.33
HPGD P15428 1/20 0.31
HTT P42858 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HDAC4 P56524 6/20 0.31
HDAC9 Q9UKV0 5/20 0.31
TP53 P04637 1/20 0.31
NCOR2 Q9Y618 1/20 0.30
CYP1A2 P05177 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13477646 0.90 MTNR1A (0.34) MTNR1AMTNR1BHDAC3HDAC1HDAC6
SCHEMBL13477645 0.81 HSP90AA1 (0.32) HDAC3HDAC1HDAC6HDAC8HSP90AA1
SCHEMBL13833713 0.78 HSP90AA1 (0.42) HSP90AA1
SCHEMBL20879031 0.74 HDAC3 (0.39) MTNR1AMTNR1BHDAC3HDAC1HDAC6
SCHEMBL20879118 0.74 MTNR1A (0.44) MTNR1AMTNR1BHDAC3HDAC1HDAC6
SCHEMBL501271 0.73 HSP90AB1 (0.51) HSP90AA1
SCHEMBL500655 0.72 HSP90AB1 (0.50) HSP90AA1
SCHEMBL22667590 0.69 CA12 (0.42)
SCHEMBL15604263 0.68 ERBB2 (0.40) MTNR1AMTNR1BHDAC3HDAC1HDAC6
SCHEMBL20879039 0.68 TDP1 (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010017545-A2 TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY SYNTA PHARAMCEUTICALS CORP. (US) 2010-02-11 WO disclosed