Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11802472 | 0.90 | CYP1A2 (0.56) | KMT2AMEN1NPC1RAB9AAPP | |
| SCHEMBL23679247 | 0.89 | KMT2A (0.50) | KMT2AMEN1NPC1RAB9AAPP | |
| SCHEMBL11736716 | 0.87 | KMT2A (0.51) | KMT2AMEN1NPC1RAB9AAPP | |
| SCHEMBL947416 | 0.83 | GAA (0.58) | KMT2AAPPMAPTGAAALDH1A1 | |
| SCHEMBL16383974 | 0.82 | APP (0.51) | KMT2AMEN1NPC1RAB9AAPP | |
| SCHEMBL27778851 | 0.82 | KMT2A (0.53) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL12017391 | 0.82 | KDM4E (0.61) | KMT2AMEN1NPC1RAB9AAPP | |
| SCHEMBL4639366 | 0.82 | NPC1 (0.56) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL27919301 | 0.82 | HTR1B (0.46) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL20983500 | 0.81 | APP (0.50) | KMT2AMEN1NPC1RAB9AAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778677-B1 | HETEROCYCLIC CONDENSED COMPOUNDS USEFUL AS ANTIDIURETIC AGENTS | VANTIA LTD (GB) | 2010-02-03 | — | — | EP | disclosed |